Description

O1-tert-Butyl O4-Ethyl (3S,4S)-3-Hydroxypiperidine-1,4-Dicarboxylate is a high-purity, stereochemically defined chiral piperidine derivative. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) for the synthesis of complex bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in areas requiring precise stereochemical control.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Synthesis: Used in stereoselective chemical reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to develop new drug molecules.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Protease Inhibitor Synthesis: Potential intermediate in the synthesis of inhibitors targeting specific enzymes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	O1-tert-Butyl O4-Ethyl (3S,4S)-3-Hydroxypiperidine-1,4-Dicarboxylate
CAS No.	2271349-56-3
Molecular Formula	C13H23NO5
Molecular Weight	273.33 g/mol
Synonyms	(3S,4S)-1-(tert-Butoxycarbonyl)-4-(ethoxycarbonyl)-3-hydroxypiperidine; 1-Boc-4-(COOEt)-3-hydroxypiperidine (3S,4S)-isomer; tert-Butyl (3S,4S)-4-(ethoxycarbonyl)-3-hydroxypiperidine-1-carboxylate; (3S,4S)-3-Hydroxy-1,4-piperidinedicarboxylic acid 1-tert-butyl 4-ethyl ester; 2271349-56-3; (3S,4S)-Boc-4-COOEt-3-OH-piperidine; (3S,4S)-1-N-Boc-4-ethoxycarbonyl-3-piperidinol
EINECS	Contact for details

Quality Control

Our O1-tert-Butyl O4-Ethyl (3S,4S)-3-Hydroxypiperidine-1,4-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to confirm stereochemical purity and identity. We provide Certificates of Analysis (COA) with detailed specifications for purity, related substances, and residual solvents, ensuring compliance with cGMP guidelines for advanced intermediates. Our quality commitment supports your regulatory filings and process validation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.