Description

Pomalidomide-Peg4-Azide CAS NO 2271036-47-4 is a high-purity, bifunctional chemical linker designed for advanced bioconjugation and PROTAC (Proteolysis Targeting Chimera) development. This compound is critical for researchers and pharmaceutical developers creating targeted therapeutic agents by enabling precise, site-specific attachment of payloads to biological molecules. It is primarily utilized in the synthesis of antibody-drug conjugates (ADCs), targeted protein degraders, and other sophisticated chemical biology tools within the pharmaceutical, biotechnology, and life sciences research sectors.

Application

• PROTAC & Molecular Glue Synthesis: Serves as a key building block for constructing heterobifunctional degraders that link E3 ubiquitin ligase ligands to target protein binders.
• Antibody-Drug Conjugate (ADC) Development: Enables the controlled, site-specific conjugation of cytotoxic drugs or imaging agents to monoclonal antibodies via its azide and PEGylated linker.
• Chemical Biology & Probe Design: Used to create activity-based probes and affinity labels for target identification and validation studies.
• Peptide & Protein Modification: Facilitates the functionalization of peptides, proteins, and other biomolecules with pomalidomide derivatives for targeted delivery.
• Materials Science & Surface Functionalization: Applied in modifying surfaces and nanomaterials with bioactive molecules for diagnostic and therapeutic platforms.
• Preclinical Research: Essential for academic and industrial R&D focused on novel targeted cancer therapies and protein homeostasis modulation.

Basic Information

Product Name	Pomalidomide-Peg4-Azide
CAS No.	2271036-47-4
Molecular Formula	C31H39N7O9
Molecular Weight	653.69 g/mol
Synonyms	Pomalidomide-PEG4-N3; 4-((17-Azido-3,6,9,12-tetraoxa-16-azaheptadecyl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; CC-4047-PEG4-Azide; Pomalidomide-PEG4-Azide; Pomalidomide PEG4 Azide; Pomalidomide-(PEG)4-N3; Azido-PEG4-Pomalidomide; N3-PEG4-Pomalidomide
EINECS	Contact for details

Quality Control

Our Pomalidomide-Peg4-Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We support compliance with relevant research and development guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.