Description

4-((2-(2-(2-Azidoethoxy)Ethoxy)Ethyl)Amino)-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione is a high-purity, functionalized chemical building block designed for advanced research and development. This compound is critical for applications requiring precise molecular conjugation, particularly in the development of targeted biopharmaceuticals and novel chemical probes. It is primarily utilized by research scientists and process development chemists in the pharmaceutical, biotechnology, and life science sectors.

Application

• PROTAC (Proteolysis Targeting Chimera) Linker Synthesis: Serves as a key component for constructing heterobifunctional molecules that facilitate targeted protein degradation.
• Antibody-Drug Conjugate (ADC) Development: Used as a specialized linker-payload intermediate, enabling the attachment of cytotoxic agents to monoclonal antibodies via click chemistry.
• Chemical Biology & Probe Design: Enables the site-specific labeling and functionalization of biomolecules (proteins, nucleic acids) for imaging, diagnostic, and mechanistic studies.
• Bioconjugation & Click Chemistry: The azide group allows for efficient, bioorthogonal copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC) reactions.
• Pharmaceutical Intermediate: Acts as a sophisticated precursor in the synthesis of novel small-molecule therapeutics, especially in oncology.
• Polymer & Materials Science: Can be incorporated into functional polymers or surfaces to introduce bioactive or degradable properties.

Basic Information

Product Name	4-((2-(2-(2-Azidoethoxy)Ethoxy)Ethyl)Amino)-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione
CAS No.	2271036-45-2
Molecular Formula	C21H25N7O7
Molecular Weight	487.47 g/mol
Synonyms	4-((2-(2-(2-Azidoethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; Thalidomide-PEG3-azide; Thalidomide-PEG3-N3; Lenalidomide-PEG3-azide; E3 Ligase Ligand-PEG3-Azide; Cereblon Ligand-PEG3-Azide; PROTAC Linker-Payload Intermediate; Azido-PEG3-thalidomide
EINECS	Contact for details

Quality Control

Our 4-((2-(2-(2-Azidoethoxy)Ethoxy)Ethyl)Amino)-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at -20°C or below under an inert atmosphere. The material is moisture-sensitive; ensure the container is kept in a dry environment and allowed to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.