Description

6-Bromo-2,2-Difluoro-Spiro[3.3]heptane is a high-value, multifunctional spirocyclic building block designed for advanced organic synthesis. This compound matters for its unique three-dimensional structure and the strategic placement of bromine and fluorine atoms, which enable precise molecular modifications and the introduction of desirable physicochemical properties. Pharmaceutical, agrochemical, and advanced materials researchers need it to develop novel active ingredients, functional polymers, and complex chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon for constructing spirocyclic cores in drug discovery programs targeting CNS disorders, metabolic diseases, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoro and bromo groups enhance biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for sophisticated chiral ligands and organocatalysts in asymmetric synthesis.
• Advanced Material Precursor: Incorporated into specialty polymers, liquid crystals, and organic electronic materials to tune electronic properties and molecular packing.
• Fluorine Chemistry Research: An essential reagent for studying the effects of gem-difluoro substitution on molecular conformation and reactivity in spiro systems.
• Cross-Coupling Reactions: The bromine atom acts as a handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to form complex carbon-carbon bonds.

Basic Information

Product Name	6-Bromo-2,2-Difluoro-Spiro[3.3]heptane
CAS No.	2260937-26-4
Molecular Formula	C7H7BrF2
Molecular Weight	209.03 g/mol
Synonyms	6-Bromo-2,2-difluorospiro[3.3]heptane; 2,2-Difluoro-6-bromospiro[3.3]heptane; Spiro[3.3]heptane, 6-bromo-2,2-difluoro-; 6-Bromo-2,2-difluoro-spiro[3.3]heptane; BDFS; 2260937-26-4
EINECS	Contact for details

Quality Control

Our 6-Bromo-2,2-Difluoro-Spiro[3.3]heptane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.