Description

Pyrido[2,3-D]Pyrimidin-2(1H)-One, 4,7-Dichloro-6-Fluoro-1-[4-Methyl-2-(1-Methylethyl)-3-Pyridinyl]- is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of novel active pharmaceutical ingredients (APIs). This compound is critical for medicinal chemistry research and development, offering a sophisticated heterocyclic scaffold for targeting specific biological pathways. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of next-generation therapeutics, particularly in oncology and antiviral research.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel small-molecule drug candidates.
• Kinase Inhibitor Development: Core scaffold for research into targeted cancer therapies, particularly for kinase-related pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes.
• Preclinical API Synthesis: Essential for producing compounds for in vitro and in vivo biological testing.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development.
• Academic Research: Utilized in university and institutional labs for chemical biology and drug discovery projects.

Basic Information

Product Name	Pyrido[2,3-D]Pyrimidin-2(1H)-One, 4,7-Dichloro-6-Fluoro-1-[4-Methyl-2-(1-Methylethyl)-3-Pyridinyl]-
CAS No.	2252403-83-9
Molecular Formula	C16H13Cl2FN4O
Molecular Weight	367.21 g/mol
Synonyms	4,7-Dichloro-6-fluoro-1-(4-methyl-2-(propan-2-yl)pyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one; 4,7-Dichloro-6-fluoro-1-(4-methyl-2-isopropylpyridin-3-yl)-1,2-dihydropyrido[2,3-d]pyrimidin-2-one; 1-(4-Methyl-2-isopropyl-3-pyridinyl)-4,7-dichloro-6-fluoro-1,2-dihydropyrido[2,3-d]pyrimidin-2-one; CAS 2252403-83-9; Pyrido[2,3-d]pyrimidin-2(1H)-one derivative; Dichlorofluoro pyridopyrimidinone intermediate.
EINECS	Contact for details

Quality Control

Our Pyrido[2,3-D]Pyrimidin-2(1H)-One intermediate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis to ensure compliance with ICH Q3C guidelines. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.