Description

2,6-Dichloro-5-Fluoro-n-((2-Isopropyl-4-Methylpyridin-3-Yl)Carbamoyl)Nicotinamide is a high-purity, advanced pharmaceutical intermediate of significant commercial interest. This compound is valued for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily sought by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of target drug molecules, especially those with pyridine and nicotinamide core structures.
• Drug Discovery & Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• API Synthesis: Serves as a building block in the commercial-scale production of active pharmaceutical ingredients, where consistent quality is paramount.
• Contract Manufacturing: Supplied to CDMOs for custom synthesis projects and process optimization for client-specific molecules.
• Chemical Reference Standard: Can be utilized as a high-purity standard for analytical method development and quality control in pharmaceutical labs.

Basic Information

Product Name	2,6-Dichloro-5-Fluoro-n-((2-Isopropyl-4-Methylpyridin-3-Yl)Carbamoyl)Nicotinamide
CAS No.	2252403-81-7
Molecular Formula	C16H15Cl2FN4O2
Molecular Weight	385.22 g/mol
Synonyms	2,6-Dichloro-5-fluoro-N-[(2-isopropyl-4-methylpyridin-3-yl)carbamoyl]pyridine-3-carboxamide; 2,6-Dichloro-5-fluoro-3-[[[(2-isopropyl-4-methyl-3-pyridinyl)amino]carbonyl]carbamoyl]pyridine; Nicotinamide, 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methyl-3-pyridinyl)carbamoyl)-; CAS 2252403-81-7
EINECS	Contact for details

Quality Control

Our 2,6-Dichloro-5-Fluoro-n-((2-Isopropyl-4-Methylpyridin-3-Yl)Carbamoyl)Nicotinamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is likely light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.