Description

6-Bromospiro[Indoline-3,3'-Pyrrolidin]-2-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic molecular architecture. This compound is of significant value in medicinal chemistry for its role as a key building block in the research and development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of bioactive molecules targeting central nervous system disorders and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those with spirocyclic or fused heterocyclic structures.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Proteolysis-Targeting Chimera (PROTAC) Development: Used in the construction of linker-warhead conjugates for targeted protein degradation platforms.
• Chemical Biology Probes: Employed in the development of tool compounds for investigating biological pathways and target validation.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for custom synthesis and scale-up projects under GMP or non-GMP conditions.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and pharmacology.

Basic Information

Product Name	6-Bromospiro[Indoline-3,3'-Pyrrolidin]-2-One Hydrochloride
CAS No.	2247105-73-1
Molecular Formula	C12H12BrN2O • HCl
Molecular Weight	331.60 g/mol (Free base: 295.14 g/mol)
Synonyms	6-Bromospiro[indoline-3,3'-pyrrolidin]-2-one HCl; 6-Bromo-2-oxospiro[indoline-3,3'-pyrrolidine] hydrochloride; 6-Bromo-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine] hydrochloride; 6-Bromo-1,2-dihydrospiro[indole-3,3'-pyrrolidin]-2-one hydrochloride; 6-Bromospiro[indole-3,3'-pyrrolidin]-2(1H)-one hydrochloride; 2247105-73-1; Spiro[indoline-3,3'-pyrrolidine] derivative
EINECS	Contact for details

Quality Control

Our 6-Bromospiro[Indoline-3,3'-Pyrrolidin]-2-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and KF for moisture content, to ensure it meets the stringent requirements of pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support custom synthesis to meet specific purity or analytical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.