Description

n-(2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pivalamide is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester group. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing complex biaryl systems. It is an essential building block for research and development chemists in the pharmaceutical and agrochemical industries who require reliable, high-quality precursors for drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing complex fluorinated biaryl structures.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boron reagent for palladium-catalyzed carbon-carbon bond formation, enabling the construction of novel chemical entities.
• Drug Discovery & Medicinal Chemistry: Used in high-throughput screening and lead optimization to create libraries of compounds for biological evaluation.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and insecticides that require specific fluorinated aromatic motifs.
• Material Science: Potential building block for organic electronic materials, such as OLEDs and semiconductors, where precise molecular architecture is critical.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the life sciences sector.

Basic Information

Product Name	n-(2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pivalamide
CAS No.	2246895-97-4
Molecular Formula	C17H25BFNO3
Molecular Weight	321.20 g/mol
Synonyms	2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2,2-dimethylpropanoyl)aniline; Pivalamide, N-[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline pivalamide; 2246895-97-4; 2-Fluoro-4-(pinacolatoboron)-N-pivaloylaniline; N-(2-Fluoro-4-(pinacolboron)phenyl)pivalamide
EINECS	Contact for details

Quality Control

Our n-(2-Fluoro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pivalamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP guidelines for advanced intermediates, ensuring reliability for your most demanding synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.