Description

n-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pentanamide is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) targets.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, especially those requiring biaryl or substituted phenyl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: The protected boronic acid moiety allows for efficient, palladium-catalyzed carbon-carbon bond formation under mild conditions.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a versatile handle for introducing diverse aromatic groups into lead compounds.
• Process Chemistry & Scale-Up: Used in the development and optimization of scalable synthetic routes for potential APIs due to its stability and handling advantages over free boronic acids.
• Ligand and Material Science Precursor: Can be employed in the synthesis of specialized ligands for catalysis or organic electronic materials.

Basic Information

Item	Details
Product Name	n-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pentanamide
CAS No.	2246886-35-9
Molecular Formula	C17H26BNO3
Molecular Weight	303.21 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-pentanoylaniline; N-Pentanoyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline; N-Valeryl-3-(pinacolatoboryl)aniline; 3-Pinaneboronic acid pentanamide ester; 3-Aminophenylboronic acid pinacol ester, N-pentanoyl derivative; (3-(Pentanamido)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of n-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Pentanamide is manufactured under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.