Description

tert-Butyl 6-Bromo-1-Oxo-1,3-Dihydrospiro[Indene-2,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic structure. This compound is critical for medicinal chemistry research and development, serving as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of complex drug candidates and novel chemical entities.
• Medicinal Chemistry Research: Used as a scaffold or building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• API Synthesis: Integral to the production route of potential Active Pharmaceutical Ingredients (APIs), especially those targeting specific receptors or enzymes.
• Chemical Biology Probes: Serves as a starting material for creating specialized molecular probes used to study biological pathways and mechanisms of disease.
• Process Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.

Basic Information

Product Name	tert-Butyl 6-Bromo-1-Oxo-1,3-Dihydrospiro[Indene-2,4'-Piperidine]-1'-Carboxylate
CAS No.	2245084-41-5
Molecular Formula	C18H22BrNO3
Molecular Weight	380.28 g/mol
Synonyms	6-Bromo-1-oxo-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 6-bromo-1-oxo-1,3-dihydro-2H-spiro[indene-2,4'-piperidine]-1'-carboxylate; 1'-Boc-6-bromo-1-oxo-1,3-dihydrospiro[indene-2,4'-piperidine]; 6-Bromo-1-oxo-1,3-dihydrospiro[indene-2,4'-piperidine]-1'-carboxylic acid 1,1-dimethylethyl ester; BOC-6-Bromo-spiro[indene-1,4'-piperidine]-1'(3'H)-one; Spiro[indene-1,4'-piperidine]-1'(3'H)-one, 6-bromo-, 1'-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Bromo-1-Oxo-1,3-Dihydrospiro[Indene-2,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material is suitable for use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption. Recommended long-term storage temperature is 2-8°C (refrigerated). Allow the sealed container to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.