Description

5-Chloro-4-(Difluoromethoxy)Pyridin-2-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyridine core functionalized with chloro and difluoromethoxy groups. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular modifications. It serves as a key building block for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate halogenated heterocyclic motifs into their molecular designs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, especially for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated pyridine structure for bioactivity.
• Chemical Synthesis Building Block: Employed in organic synthesis for constructing complex molecules in medicinal chemistry and material science projects.
• Life Science Reagent: Serves as a reference standard or a specialized reagent in biochemical and pharmacological research laboratories.
• Material Science Applications: Potential use in the development of specialty polymers or functional materials requiring specific halogenated aromatic components.

Basic Information

Product Name	5-Chloro-4-(Difluoromethoxy)Pyridin-2-Amine
CAS No.	2231672-98-1
Molecular Formula	C6H5ClF2N2O
Molecular Weight	194.57 g/mol
Synonyms	5-Chloro-4-(difluoromethoxy)pyridin-2-amine; 2-Amino-5-chloro-4-(difluoromethoxy)pyridine; 4-(Difluoromethoxy)-5-chloropyridin-2-amine; 5-Chloro-4-(difluoromethoxy)-2-pyridinamine; 2231672-98-1; 5-Chloro-4-difluoromethoxypyridin-2-ylamine
EINECS	Contact for details

Quality Control

Our 5-Chloro-4-(Difluoromethoxy)Pyridin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.