Description

(S)-3-(1-Oxo-5-(Piperazin-1-Yl)Isoindolin-2-Yl)Piperidine-2,6-Dione Benzenesulfonate is a high-purity, non-racemic pharmaceutical intermediate and active ingredient with a defined stereocenter. This compound is critical for research and development in targeted protein degradation and immunomodulatory therapies, offering a key building block for novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and advanced fine chemical manufacturers engaged in the synthesis of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel Cereblon E3 Ligase Modulating Drugs (CELMoDs) and immunomodulatory imide drugs (IMiDs).
• PROTAC® (Proteolysis Targeting Chimera) Development: Serves as a critical ligand component for designing bifunctional molecules that target specific proteins for degradation.
• Oncology Research: Used in preclinical and clinical-stage research for developing targeted cancer therapies, particularly for hematological malignancies and solid tumors.
• Chemical Biology & Target Validation: Employed as a molecular tool to study protein-protein interactions and validate new therapeutic targets in cellular pathways.
• Process Chemistry & Scale-Up: Sourced by CMOs (Contract Manufacturing Organizations) for the kilogram-scale production of active pharmaceutical ingredients (APIs) under GMP conditions.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and impurity profiling of related drug substances.

Basic Information

Product Name	(S)-3-(1-Oxo-5-(Piperazin-1-Yl)Isoindolin-2-Yl)Piperidine-2,6-Dione Benzenesulfonate
CAS No.	2229714-16-1
Molecular Formula	C23H27N5O5S
Molecular Weight	485.56 g/mol
Synonyms	(S)-3-(5-(Piperazin-1-yl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione benzenesulfonate; (S)-CC-885 Benzenesulfonate; (S)-3-(1-Oxo-5-(piperazin-1-yl)isoindolin-2-yl)piperidine-2,6-dione monobenzenesulfonate; (S)-3-(5-(Piperazin-1-yl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl)piperidine-2,6-dione benzenesulfonate salt; (S)-enantiomer of CC-885 salt; PROTAC linker intermediate; CELMoD intermediate; E3 ligase modulator intermediate.
EINECS	Contact for details

Quality Control

Our production of (S)-3-(1-Oxo-5-(Piperazin-1-Yl)Isoindolin-2-Yl)Piperidine-2,6-Dione Benzenesulfonate adheres to stringent quality systems suitable for pharmaceutical development. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We employ advanced analytical techniques including HPLC, chiral HPLC, NMR, and LC-MS to ensure compliance with client specifications and internal standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere or in a controlled humidity environment to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.