Description

Pyridine, 2-[(4R)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]-6-(Diphenylmethyl)- is a sophisticated chiral oxazoline-substituted pyridine derivative, serving as a high-value building block in advanced organic synthesis. Its molecular architecture, featuring a stereogenic center and multiple aromatic systems, makes it a critical intermediate for constructing complex molecules with specific three-dimensional orientations. This compound is primarily sought after by research institutions and pharmaceutical development teams working on novel active pharmaceutical ingredients (APIs), catalysts, and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new therapeutic agents, particularly for central nervous system (CNS) and oncology targets.
• Asymmetric Catalysis: Serves as a precursor or ligand for metal complexes used in enantioselective synthesis, crucial for producing single-isomer compounds.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides where specific chirality impacts biological activity.
• Material Science: Investigated as a component for organic semiconductors, liquid crystals, or metal-organic frameworks (MOFs) due to its rigid, conjugated structure.
• Academic & Process Chemistry: Employed in methodological studies and scale-up process development for complex organic transformations.

Basic Information

Product Name	Pyridine, 2-[(4R)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]-6-(Diphenylmethyl)-
CAS No.	2227390-59-0
Molecular Formula	C27H22N2O
Molecular Weight	390.48 g/mol
Synonyms	(R)-2-(6-(Diphenylmethyl)pyridin-2-yl)-4,5-dihydro-4-phenyloxazole; 6-(Diphenylmethyl)-2-[(4R)-4,5-dihydro-4-phenyl-2-oxazolyl]pyridine; (4R)-6-(Diphenylmethyl)-2-(4,5-dihydro-4-phenyl-2-oxazolyl)pyridine; (R)-6-(Benzhydryl)-2-(4,5-dihydro-4-phenyloxazol-2-yl)pyridine; Chiral Oxazoline-Pyridine Ligand Precursor; CAS 2227390-59-0
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency critical for research and development. Identity and purity are confirmed via advanced analytical techniques including HPLC, chiral HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light). For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.