Description

2-Amino-6-Azaspiro[3.4]Octan-5-One Hydrochloride is a high-value, spirocyclic building block and advanced pharmaceutical intermediate. This compound is crucial for medicinal chemistry research and development, particularly in the synthesis of novel, complex small-molecule therapeutics. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for constructing innovative molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used for scaffold hopping and structure-activity relationship (SAR) studies to explore new chemical space and improve drug-like properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation therapeutics.
• Agrochemical Research: Employed in the discovery and development of new active ingredients with spirocyclic architectures for crop protection.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied for custom synthesis projects requiring high-purity, complex heterocyclic fragments.

Basic Information

Product Name	2-Amino-6-Azaspiro[3.4]Octan-5-One Hydrochloride
CAS No.	2227206-09-7
Molecular Formula	C7H13N3O·HCl
Molecular Weight	191.66 g/mol (Free base: 155.20 g/mol)
Synonyms	6-Azaspiro[3.4]octan-5-one, 2-amino-, hydrochloride; 2-Amino-6-azaspiro[3.4]octan-5-one HCl; 2-Amino-6-azaspiro[3.4]octan-5-one monohydrochloride; 2227206-09-7; 5(6H)-Azaspiro[3.4]octanone, 2-amino-, hydrochloride; AS-87294; BCP32863; Spiro[3.4]octane-2-amine, 6-oxo-, hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Amino-6-Azaspiro[3.4]Octan-5-One Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full analytical data are provided for each lot. We support development and commercial projects with material suitable for research use and can discuss scalable synthesis under cGMP guidelines for advanced clinical stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, low-humidity environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤5.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.