Description

1-(2,7-Diazaspiro[3.5]Nonan-2-Yl)Ethan-1-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic diaza structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel small molecule therapeutics targeting complex biological pathways. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing next-generation drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) due to its constrained, three-dimensional spirocyclic scaffold.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of bifunctional degraders.
• Chemical Biology Probes: Employed in the development of tool compounds for target validation and pathway elucidation in biological systems.
• Library Synthesis for High-Throughput Screening (HTS): A valuable scaffold for generating diverse compound libraries to identify new chemical starting points for drug discovery.

Basic Information

Product Name	1-(2,7-Diazaspiro[3.5]Nonan-2-Yl)Ethan-1-One Hydrochloride
CAS No.	2227205-94-7
Molecular Formula	C9H17N2O·HCl
Molecular Weight	204.71 g/mol (Free base: 169.25 g/mol)
Synonyms	2-Acetyl-2,7-diazaspiro[3.5]nonane hydrochloride; 1-(2,7-Diazaspiro[3.5]nonan-2-yl)ethanone HCl; 2-Acetyl-2,7-diazaspiro[3.5]nonane HCl; Ethanone, 1-(2,7-diazaspiro[3.5]nonan-2-yl)-, hydrochloride; 2227205-94-7; 2,7-Diazaspiro[3.5]nonane, 2-acetyl-, hydrochloride; Acetyl-2,7-diazaspiro[3.5]nonane hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(2,7-Diazaspiro[3.5]Nonan-2-Yl)Ethan-1-One Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for water content, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption and potential degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.