Description

6-[[2-(2,6-Dioxo-3-Piperidinyl)-2,3-Dihydro-1,3-Dioxo-1H-Isoindol-4-Yl]Amino]Hexanoic Acid is a high-purity, advanced pharmaceutical intermediate designed for research and development in targeted protein degradation. This compound is critical for the synthesis of novel Proteolysis Targeting Chimeras (PROTACs) and other bifunctional molecules, offering researchers a key building block for next-generation therapeutic discovery. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on oncology, neurodegenerative diseases, and other areas of unmet medical need.

Application

• PROTAC (Proteolysis Targeting Chimera) Linker Synthesis: Serves as a crucial component for constructing the linker region that connects the E3 ligase ligand to the target protein binder.
• Bifunctional Molecule Development: Used in the research and development of novel bifunctional degraders for targeted protein degradation (TPD) platforms.
• Chemical Biology Research: A key reagent for studying ubiquitin-proteasome system (UPS) pathways and intracellular protein regulation mechanisms.
• Preclinical Drug Candidate Synthesis: Employed in the synthesis of lead compounds for preclinical evaluation in various therapeutic areas.
• E3 Ligase Ligand Conjugation: Facilitates the attachment of payloads to ligands targeting specific E3 ubiquitin ligases, such as those from the cereblon family.

Basic Information

Product Name	6-[[2-(2,6-Dioxo-3-Piperidinyl)-2,3-Dihydro-1,3-Dioxo-1H-Isoindol-4-Yl]Amino]Hexanoic Acid
CAS No.	2225940-49-6
Molecular Formula	C23H26N4O7
Molecular Weight	470.48 g/mol
Synonyms	6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexanoic acid; (S)-6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexanoic acid; PROTAC Linker for Cereblon; E3 Ligase Ligand-Linker Conjugate; Thalidomide-O-alkyl-C6-acid; Cereblon Ligand-Linker 1; CRBN Ligand Linker Conjugate; 4-((6-Carboxyhexyl)amino)-2-(2,6-dioxo-3-piperidinyl)isoindoline-1,3-dione
EINECS	Contact for details

Quality Control

Our 6-[[2-(2,6-Dioxo-3-Piperidinyl)-2,3-Dihydro-1,3-Dioxo-1H-Isoindol-4-Yl]Amino]Hexanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (where applicable), and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.