Description

6-Cyano-4-Methylpyridine-3-Boronic Acid is a high-value, multi-functional heterocyclic boronic acid building block essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and agrochemical research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific pyridine-based scaffolds.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid reagent for palladium-catalyzed coupling with aryl/heteroaryl halides to create biaryl and heterobiaryl structures.
• Ligand and Catalyst Development: Employed in the synthesis of novel chelating ligands and organometallic catalysts for asymmetric synthesis.
• Material Science Research: A precursor for creating organic electronic materials, such as components for OLEDs or conductive polymers.
• Chemical Biology Probes: Useful in constructing molecular probes and tags for studying biological processes and target engagement.

Basic Information

Product Name	6-Cyano-4-Methylpyridine-3-Boronic Acid
CAS No.	2225178-21-0
Molecular Formula	C7H7BN2O2
Molecular Weight	161.96 g/mol
Synonyms	(6-Cyano-4-methylpyridin-3-yl)boronic acid; 3-Borono-6-cyano-4-methylpyridine; 4-Methyl-6-cyanopyridine-3-boronic acid; 6-Cyano-4-methyl-3-pyridineboronic acid; 6-Cyano-4-methylpyridine-3-boronic acid pinacol ester (protected form); 3-Pyridineboronic acid, 6-cyano-4-methyl-; Boronic acid, B-(6-cyano-4-methyl-3-pyridinyl)-
EINECS	Contact for details

Quality Control

Our 6-Cyano-4-Methylpyridine-3-Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance for critical coupling reactions. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95% (Anhydrous basis)
Water Content (KF)	≤1.0%
NMR Purity	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.