Description

5-Bromo-6-Methoxypyridine-3-Boronic Acid Pinacol Ester is a high-value, organoboron building block crucial for modern synthetic chemistry, particularly in cross-coupling reactions. Its core value lies in enabling the precise and efficient construction of complex heterocyclic scaffolds, which are foundational to advanced material and pharmaceutical research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and functional materials. The CAS number for this compound is 2223040-05-7.

Application

This versatile boronic ester is primarily employed as a key synthetic intermediate in various cutting-edge applications:

• Pharmaceutical Intermediates: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs), especially for targeted therapies and kinase inhibitors.
• Agrochemical Development: Used in creating novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a pivotal coupling partner for the formation of carbon-carbon bonds, constructing complex biaryl and heteroaryl structures.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, due to its pyridine-based structure.
• Ligand and Catalyst Synthesis: Utilized for preparing specialized ligands for metal catalysis and functional molecules for sensor technology.
• Chemical Biology Probes: Facilitates the creation of molecular probes for studying biological pathways and target engagement.

Basic Information

Item	Details
Product Name	5-Bromo-6-Methoxypyridine-3-Boronic Acid Pinacol Ester
CAS No.	2223040-05-7
Molecular Formula	C₁₂H₁₇BBrNO₃
Molecular Weight	314.0 g/mol
Synonyms	5-Bromo-6-methoxypyridin-3-ylboronic acid pinacol ester; 3-Bromo-2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Methoxy-3-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-Bromo-6-methoxy-3-pyridineboronic acid pinacol ester; (5-Bromo-6-methoxypyridin-3-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 5-Bromo-6-Methoxypyridine-3-Boronic Acid Pinacol Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (¹H, ¹³C, ¹¹B), and GC/MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.