Description

2,7-Diazaspiro[4.5]Decane-7-Carboxylic Acid, 1,1-Dimethylethyl Ester, (5S)- is a high-purity, stereochemically defined spirocyclic building block. This compound is of significant value in pharmaceutical research and development, serving as a key chiral intermediate for constructing complex molecular architectures. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, metabolic diseases, and infectious diseases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space due to its constrained spirocyclic and diaza scaffold.
• Process Chemistry Development: Serves as a starting material or advanced intermediate in the development of scalable, cost-effective synthetic routes for clinical and commercial API manufacturing.
• Library Synthesis for Drug Discovery: Employed in the generation of diverse compound libraries for high-throughput screening (HTS) against novel biological targets.
• Chemical Biology Probes: Can be incorporated into molecular probes to study enzyme function or protein-protein interactions.

Basic Information

Product Name	2,7-Diazaspiro[4.5]Decane-7-Carboxylic Acid, 1,1-Dimethylethyl Ester, (5S)-
CAS No.	2222758-66-7
Molecular Formula	C13H24N2O2
Molecular Weight	240.34 g/mol
Synonyms	(5S)-tert-Butyl 2,7-diazaspiro[4.5]decane-7-carboxylate; (5S)-7-Boc-2,7-diazaspiro[4.5]decane; (5S)-2,7-Diazaspiro[4.5]decane-7-carboxylic acid tert-butyl ester; tert-Butyl (5S)-2,7-diazaspiro[4.5]decane-7-carboxylate; (5S)-Boc-2,7-diazaspiro[4.5]decane; (5S)-7-(tert-Butoxycarbonyl)-2,7-diazaspiro[4.5]decane; (5S)-N-Boc-2,7-diazaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our 2,7-Diazaspiro[4.5]Decane-7-Carboxylic Acid, 1,1-Dimethylethyl Ester, (5S)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemistry, and consistent performance. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and impurity profiles. Our quality commitment supports compliance with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from incompatible materials such as strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.