Description

5H-Pyrazolo[4,3-C]Pyridine-5-Carboxylic Acid, 3-Amino-2-(4-Fluoro-3,5-Dimethylphenyl)-2,4,6,7-Tetrahydro-4-Methyl-, 1,1-Dimethylethyl Ester, (4S)- is a high-purity, advanced pharmaceutical intermediate featuring a complex, stereochemically defined pyrazolopyridine core. This compound is of significant value for its role as a critical building block in the synthesis of novel, targeted therapeutic agents, particularly in oncology and immunology research. It is primarily required by pharmaceutical R&D departments, process chemistry teams, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the development of next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of investigational new drugs (INDs) and new chemical entities (NCEs).
• Oncology Drug Discovery: Serves as a core scaffold for developing kinase inhibitors and other targeted cancer therapies.
• Process Chemistry & Scale-Up: Used in route scouting, optimization, and cGMP manufacturing for clinical trial material (CTM) production.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and lead optimization campaigns due to its modifiable functional groups.
• Custom Synthesis: A starting material for contract research organizations (CROs) and pharmaceutical companies developing proprietary compound libraries.
• API Development: Integral in the synthetic pathway towards complex Active Pharmaceutical Ingredients (APIs) requiring high stereochemical purity.

Basic Information

Item	Details
Product Name	5H-Pyrazolo[4,3-C]Pyridine-5-Carboxylic Acid, 3-Amino-2-(4-Fluoro-3,5-Dimethylphenyl)-2,4,6,7-Tetrahydro-4-Methyl-, 1,1-Dimethylethyl Ester, (4S)-
CAS No.	2212021-59-3
Molecular Formula	C21H27FN4O2
Molecular Weight	386.47 g/mol
Synonyms	(4S)-3-Amino-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester; tert-Butyl (4S)-3-amino-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-4,6,7,8-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate; (S)-tert-Butyl 3-amino-2-(4-fluoro-3,5-dimethylphenyl)-4-methyl-4,7-dihydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate; UNII-Contact for details; SCHEMBL-Contact for details; Advanced Pharmaceutical Intermediate 2212021-59-3; Chiral Pyrazolopyridine Ester
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to stringent quality protocols suitable for pharmaceutical development. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and chiral integrity. Comprehensive Certificates of Analysis (COA) are provided, detailing all critical quality attributes. We support development under quality agreements and can align with cGMP guidelines for advanced phase manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed in a dry environment. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.