Description

6-(Trifluoromethyl)-2-Azaspiro[3.3]Heptane Hydrochloride is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and trifluoromethylated structure. This compound is critical for medicinal chemistry research and development, offering significant potential to modulate the pharmacokinetic and metabolic properties of new drug candidates. It is primarily sought after by R&D teams and process chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small molecule drugs, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to introduce spirocyclic rigidity and fluorine atoms, improving metabolic stability and binding affinity.
• Agrochemical Synthesis: Serves as a precursor for developing new generation pesticides and herbicides with enhanced efficacy and environmental profile.
• Chemical Biology Probes: Utilized in the creation of tool compounds for target validation and pathway analysis in biological systems.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Ligand & Catalyst Development: Acts as a sophisticated scaffold for designing novel ligands and organocatalysts in asymmetric synthesis.

Basic Information

Product Name	6-(Trifluoromethyl)-2-Azaspiro[3.3]Heptane Hydrochloride
CAS No.	2209112-05-8
Molecular Formula	C8H11ClF3N
Molecular Weight	213.63 g/mol
Synonyms	2-Azaspiro[3.3]heptane, 6-(trifluoromethyl)-, hydrochloride; 6-(Trifluoromethyl)-2-azaspiro[3.3]heptane HCl; 6-(Trifluoromethyl)-2-azaspiro[3.3]heptane hydrochloride; 6-(Trifluoromethyl)-2-azaspiro[3.3]heptane monohydrochloride; 2-Azaspiro[3.3]heptane, 6-(trifluoromethyl)-, monohydrochloride; (6-(Trifluoromethyl)-2-azaspiro[3.3]heptan-2-yl) hydrochloride
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)-2-Azaspiro[3.3]Heptane Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to prevent degradation upon exposure to air.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.