Description

5-Azaspiro[2.4]Heptane-7-Carboxylic Acid, Methyl Ester, Hydrochloride (1:1) is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained spirocyclic scaffold.
• API Synthesis: Incorporated into the final synthetic steps for producing complex small-molecule APIs requiring this specific spiro-heterocyclic moiety.
• Chemical Biology Probes: Serves as a scaffold for developing tool compounds and probes to study biological pathways and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the pharmaceutical industry.

Basic Information

Product Name	5-Azaspiro[2.4]Heptane-7-Carboxylic Acid, Methyl Ester, Hydrochloride (1:1)
CAS No.	2207870-15-1
Molecular Formula	C8H13NO2 • HCl
Molecular Weight	191.65 g/mol (Free base: 155.19 g/mol)
Synonyms	Methyl 5-azaspiro[2.4]heptane-7-carboxylate hydrochloride; 5-Azaspiro[2.4]heptane-7-carboxylic acid methyl ester hydrochloride; 7-Methoxycarbonyl-5-azaspiro[2.4]heptane hydrochloride; Azaspiroheptane carboxylate methyl ester HCl; Spiro[cyclopropane-1,2'-pyrrolidine]-5'-carboxylic acid, methyl ester, hydrochloride
EINECS	Contact for details

Quality Control

Our 5-Azaspiro[2.4]Heptane-7-Carboxylic Acid, Methyl Ester, Hydrochloride (1:1) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.