Description

tert-Butyl 7-Oxo-1-Azaspiro[4.4]Nonane-1-Carboxylate is a high-value, protected spirocyclic lactam building block used in advanced organic synthesis. This compound is critical for medicinal chemistry research and development, serving as a key intermediate in the construction of complex, biologically active molecules. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers for the synthesis of novel drug candidates targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A versatile scaffold for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR).
• Protease Inhibitor Development: The spirocyclic lactam core is a privileged structure in the design of enzyme inhibitors.
• Chemical Biology Probes: Serves as a building block for creating tool compounds to study biological pathways and target validation.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for clients.
• Library Synthesis: Enables the generation of diverse compound libraries for high-throughput screening (HTS) in drug discovery.

Basic Information

Product Name	tert-Butyl 7-Oxo-1-Azaspiro[4.4]Nonane-1-Carboxylate
CAS No.	2206825-58-1
Molecular Formula	C13H21NO3
Molecular Weight	239.31 g/mol
Synonyms	1-Boc-7-oxo-1-azaspiro[4.4]nonane; 1-(tert-Butoxycarbonyl)-7-oxo-1-azaspiro[4.4]nonane; 7-Oxo-1-azaspiro[4.4]nonane-1-carboxylic acid tert-butyl ester; tert-Butyl 7-oxo-1-azaspiro[4.4]nonane-1-carboxylate; Boc-7-oxo-1-azaspiro[4.4]nonane; 1-Azaspiro[4.4]nonane-7-one, 1-(1,1-dimethylethoxy)carbonyl]-; 1-N-Boc-7-oxo-1-azaspiro[4.4]nonane
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Standard analytical techniques including HPLC, GC, NMR, and MS are employed to guarantee the integrity and consistency of this advanced intermediate, supporting critical R&D and cGMP manufacturing workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.