Description

(5-Chloropyridin-3-Yl)(Cyclopropyl)Methanamine Dihydrochloride CAS NO 2197061-67-7 is a high-purity, advanced pharmaceutical intermediate featuring a chloropyridine core and a cyclopropylamine moiety. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates, especially in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its unique scaffold.
• Agrochemical Synthesis: Serves as a precursor in the development of new pesticides and herbicides.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for target identification and validation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring a functionalized pyridine derivative.
• Academic Research: Employed in university and institutional labs for methodological development and novel heterocyclic chemistry.

Basic Information

Product Name	(5-Chloropyridin-3-Yl)(Cyclopropyl)Methanamine Dihydrochloride
CAS No.	2197061-67-7
Molecular Formula	C9H12Cl3N2
Molecular Weight	254.56 g/mol
Synonyms	Cyclopropyl(5-chloro-3-pyridinyl)methanamine dihydrochloride; (5-Chloro-3-pyridyl)(cyclopropyl)methanamine dihydrochloride; 1-(5-Chloropyridin-3-yl)-1-cyclopropylmethanamine dihydrochloride; (5-Chloro-3-pyridinyl)(cyclopropyl)methanamine hydrochloride (1:2); N-Cyclopropyl-5-chloronicotinamide dihydrochloride (precursor-related); 5-Chloro-N-cyclopropylnicotinamide dihydrochloride (precursor-related); CAS 2197061-67-7
EINECS	Contact for details

Quality Control

Our (5-Chloropyridin-3-Yl)(Cyclopropyl)Methanamine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Assay (Titration)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.