Description

n-[2-Methyl-3-(Trifluoromethyl)Phenyl]-N'-[2-Methyl-6-(Trifluoromethyl)Pyridin-3-Yl]Urea is a high-purity, advanced pharmaceutical intermediate characterized by its unique diaryl urea structure incorporating trifluoromethyl groups. This compound matters for its critical role in the research and development of novel small-molecule therapeutics, particularly in kinase inhibition and targeted oncology. Industrial and academic researchers in the pharmaceutical, agrochemical, and advanced materials sectors require this precise chemical building block for developing next-generation active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of targeted kinase inhibitors for oncology and inflammatory disease research.
• Agrochemical Research: Used in developing novel active ingredients for crop protection with potential herbicidal or fungicidal activity.
• Chemical Biology Probe: Serves as a core structure for creating molecular probes to study specific enzyme functions and signaling pathways.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies due to its modifiable diaryl urea scaffold and lipophilic trifluoromethyl groups.
• Preclinical Candidate Synthesis: Employed in the scale-up synthesis of lead compounds for preclinical evaluation and development.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke chemical synthesis projects.

Basic Information

Product Name	n-[2-Methyl-3-(Trifluoromethyl)Phenyl]-N'-[2-Methyl-6-(Trifluoromethyl)Pyridin-3-Yl]Urea
CAS No.	2197055-55-1
Molecular Formula	C₁₆H₁₃F₆N₃O
Molecular Weight	377.29 g/mol
Synonyms	1-(2-Methyl-3-(trifluoromethyl)phenyl)-3-(2-methyl-6-(trifluoromethyl)pyridin-3-yl)urea; N-(2-Methyl-3-(trifluoromethyl)phenyl)-N'-(2-methyl-6-(trifluoromethyl)pyridin-3-yl)urea; Diarylyl Urea Derivative CAS 2197055-55-1; Urea, N-[2-methyl-3-(trifluoromethyl)phenyl]-N'-[2-methyl-6-(trifluoromethyl)-3-pyridinyl]-; 3-Pyridinecarboxamide, N-[2-methyl-3-(trifluoromethyl)phenyl]-N'-(2-methyl-6-(trifluoromethyl)-3-pyridinyl)-; TFMP-TFMP Urea; Kinase Inhibitor Intermediate 2197055-55-1
EINECS	Contact for details

Quality Control

Our n-[2-Methyl-3-(Trifluoromethyl)Phenyl]-N'-[2-Methyl-6-(Trifluoromethyl)Pyridin-3-Yl]Urea is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We support compliance with cGMP and ISO 9001 standards for pharmaceutical intermediate supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.