Description

2-Azabicyclo[2.2.1]Heptane-2-Carboxylic Acid, 6-Hydroxy-, Phenylmethyl Ester, (1R,4S,6R)- is a high-purity, stereochemically defined bicyclic amino acid derivative. This compound matters as a sophisticated chiral building block, enabling the synthesis of complex molecules with precise three-dimensional architecture. It is primarily needed by pharmaceutical R&D and process chemistry teams for developing active pharmaceutical ingredients (APIs), particularly in the areas of neurology and metabolic disease.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents and active pharmaceutical ingredients (APIs).
• Peptidomimetic Chemistry: Used to construct constrained peptide analogs and mimetics to enhance metabolic stability and receptor selectivity.
• Asymmetric Synthesis: Serves as a precursor or catalyst ligand in stereoselective organic synthesis due to its rigid bicyclic framework.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: A critical component for fine chemical manufacturers offering bespoke synthesis services for the life sciences industry.

Basic Information

Item	Details
Product Name	2-Azabicyclo[2.2.1]Heptane-2-Carboxylic Acid, 6-Hydroxy-, Phenylmethyl Ester, (1R,4S,6R)-
CAS No.	2195385-11-4
Molecular Formula	C14H17NO3
Molecular Weight	247.29 g/mol
Synonyms	(1R,4S,6R)-6-Hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylic acid phenylmethyl ester; (1R,4S,6R)-6-Hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylic acid benzyl ester; 6-Hydroxy-2-azanorbornane-2-carboxylic acid benzyl ester; (1R,4S,6R)-6-Hydroxy-2-azanorbornane-2-carboxylate benzyl ester; Benzyl (1R,4S,6R)-6-hydroxy-2-azabicyclo[2.2.1]heptane-2-carboxylate; Chiral bicyclic amino acid ester; 2-Azabicyclo[2.2.1]heptane carboxylate derivative
EINECS	Contact for details

Quality Control

Our 2-Azabicyclo[2.2.1]Heptane-2-Carboxylic Acid, 6-Hydroxy-, Phenylmethyl Ester, (1R,4S,6R)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting pharmaceutical-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.