Description

Azido-Peg4-Nitrile is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive azide group and a nitrile terminus. This compound is essential for facilitating click chemistry reactions, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling the precise conjugation of biomolecules and materials. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotech, and materials science industries for applications in drug delivery system development, bioconjugation, and surface functionalization.

Application

• Bioconjugation and ADC Development: Used as a crosslinker for attaching cytotoxic drugs, fluorescent dyes, or other payloads to antibodies, proteins, or peptides.
• Drug Delivery System Fabrication: Facilitates the surface modification of nanoparticles, liposomes, and polymeric micelles to enhance targeting and stability.
• Materials Science and Surface Engineering: Enables the functionalization of surfaces, hydrogels, and scaffolds for biomedical and diagnostic applications.
• Click Chemistry Reagent: Serves as a key reagent in CuAAC reactions for the rapid and modular synthesis of complex molecular architectures.
• Proteomics and Biomolecule Labeling: Utilized for site-specific labeling of proteins and other biomolecules for analytical and diagnostic purposes.
• Polymer Chemistry: Acts as a functional monomer or chain extender in the synthesis of advanced functional polymers.

Basic Information

Product Name	Azido-Peg4-Nitrile
CAS No.	2194563-82-9
Molecular Formula	C15H26N4O4
Molecular Weight	326.39 g/mol
Synonyms	Azido-PEG4-CN; 2,5,8,11-Tetraoxatetradecan-14-nitrile, 14-azido-; 14-Azido-2,5,8,11-tetraoxatetradecan-14-nitrile; Azido tetraethylene glycol cyanomethyl ether; N3-PEG4-CN; Azido-PEG4-Cyanomethyl Ether; PEG4-Azide-CN; Azido-PEG4-nitrile
EINECS	Contact for details

Quality Control

Our Azido-Peg4-Nitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.