Description

n-(Azido-PEG3)-NH-PEG3-acid HCl salt is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group and a carboxylic acid, presented as its hydrochloride salt. This compound is essential for creating stable, biocompatible conjugates in bioconjugation and materials science, leveraging click chemistry for efficient and selective coupling. It is primarily needed by researchers and manufacturers in pharmaceutical development, proteomics, and advanced material synthesis for constructing drug delivery systems, diagnostic probes, and functionalized surfaces.

Application

• Bioconjugation and ADC Development: Used as a key linker for attaching cytotoxic drugs to antibodies via its azide group, forming Antibody-Drug Conjugates (ADCs) with a hydrophilic PEG spacer to improve solubility and pharmacokinetics.
• Proteomics and Biomolecule Labeling: Facilitates the site-specific labeling of proteins, peptides, and oligonucleotides through copper-free or strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry.
• Polymer and Materials Functionalization: Serves as a building block for modifying surfaces, nanoparticles, and hydrogels with bioactive ligands or fluorescent tags via its carboxylic acid terminus.
• Crosslinking Agent: Acts as a heterobifunctional crosslinker to bridge amine-containing and alkyne-containing molecules, creating stable triazole linkages for studying biomolecular interactions.
• Diagnostic Reagent Synthesis: Employed in the construction of imaging probes and contrast agents for in vitro and in vivo diagnostics, leveraging the bioorthogonal nature of the azide group.
• Peptide and Protein Modification: Enables the PEGylation (pegylation) of therapeutic peptides and proteins to enhance stability, reduce immunogenicity, and prolong circulation half-life.

Basic Information

Product Name	n-(Azido-PEG3)-NH-PEG3-acid HCl salt
CAS No.	2183440-72-2
Molecular Formula	C16H32ClN5O8
Molecular Weight	481.91 g/mol
Synonyms	Azido-PEG3-amine-PEG3-acid HCl salt; 3-Azidopropyl-[2-[2-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethoxy]ethyl]carbamate hydrochloride; 11-Azido-3,6,9-trioxa-2-azaundecan-1-oic acid, 2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethyl ester hydrochloride; N-(Azido-PEG3)-amino-PEG3-acid hydrochloride; Azido-PEG3-NH-PEG3-COOH·HCl; Heterobifunctional PEG linker, Azide-PEG3-amine-PEG3-acid HCl; PEG-based azido-amine-acid crosslinker HCl salt
EINECS	Contact for details

Quality Control

Our n-(Azido-PEG3)-NH-PEG3-acid HCl salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support compliance with relevant guidelines for pharmaceutical intermediate use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant in a dry, freezer environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF, methanol; partially soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.