Description

n-(Azido-Peg3)-n-(Peg2-Amine)-Peg3-Acid CAS NO 2183440-70-0 is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group, a secondary amine, and a carboxylic acid terminal, designed for advanced bioconjugation and materials science applications. This compound matters for its ability to facilitate multi-step, orthogonal coupling strategies, enabling the precise construction of complex biomolecular architectures and functionalized surfaces. It is essential for researchers and manufacturers in pharmaceutical development, particularly for antibody-drug conjugate (ADC) synthesis, peptide modification, and the creation of hydrogel networks and diagnostic probes.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key intermediate for constructing cleavable or non-cleavable linkers, connecting cytotoxic payloads to monoclonal antibodies via click chemistry and amide bond formation.
• Peptide and Protein Modification: Enables site-specific PEGylation to enhance pharmacokinetic properties, solubility, and stability of therapeutic peptides and proteins.
• Surface Functionalization: Used to create biofunctional coatings on nanoparticles, biosensors, and microarray slides for targeted binding and assay development.
• Hydrogel and Biomaterial Synthesis: Acts as a cross-linking agent or functional monomer in the development of biocompatible hydrogels for drug delivery and tissue engineering.
• Diagnostic Reagent Development: Facilitates the conjugation of dyes, quenchers, or other reporter molecules to targeting ligands for in vitro diagnostics (IVD).
• Polymer Chemistry: A versatile building block for synthesizing functionalized block copolymers with tailored properties for nanotechnology applications.

Basic Information

Product Name	n-(Azido-Peg3)-n-(Peg2-Amine)-Peg3-Acid
CAS No.	2183440-70-0
Molecular Formula	C24H46N6O11
Molecular Weight	618.66 g/mol
Synonyms	Azido-PEG3-PEG2-Amine-PEG3-Acid; 2-[2-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl-[2-[2-(2-carboxyethoxy)ethoxy]ethyl]amino]ethoxy]ethoxy]acetic Acid; 3-[2-[2-[2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl-[2-[2-(2-carboxyethoxy)ethoxy]ethyl]amino]ethoxy]ethoxy]propanoic Acid; Heterobifunctional PEG Linker, N3-PEG3-NH-PEG2-PEG3-COOH; Azide-PEG3-Amine(PEG2)-PEG3-Acid; 15-Azido-4,7,10,13-tetraoxa-3-aza-1(2,5,8,11,14-pentaoxa-3-azahexadec-16-yl)hexadecan-16-oic Acid
EINECS	Contact for details

Quality Control

Our n-(Azido-Peg3)-n-(Peg2-Amine)-Peg3-Acid is manufactured under a quality management system and undergoes rigorous analytical testing to ensure batch-to-batch consistency and high purity for research and development. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as purity (by HPLC), identity confirmation (by NMR and MS), and functional group integrity. We support development projects requiring compliance with cGMP guidelines for non-GMP starting materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant in a freezer dedicated for chemicals. This product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and exposure.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (Azide)	≥ 90% of theoretical
Functional Group Assay (Acid)	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.