Description

n-(Acid-Peg3)-n-Bis(Peg3-Azide) is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a carboxylic acid group and two azide termini, enabling orthogonal conjugation chemistries. This compound is critical for creating stable, well-defined bioconjugates and functionalized materials through efficient click chemistry and amide bond formation. It is primarily needed by researchers and manufacturers in biopharmaceutical development, proteomics, and advanced materials science for applications such as drug delivery system assembly and surface functionalization.

Application

• Bioconjugation and ADC Development: Used as a versatile linker for attaching payloads (e.g., drugs, toxins, fluorophores) to antibodies, proteins, or peptides via its orthogonal acid and azide groups.
• PEGylation and Hydrogel Formation: Serves as a crosslinking agent to introduce PEG spacers into hydrogels or polymeric networks, enhancing biocompatibility and solubility.
• Surface Functionalization: Enables the modification of nanoparticles, chips, or other solid supports with bioactive molecules for biosensing and diagnostic applications.
• Click Chemistry Scaffolds: Acts as a core building block in Cu-free or strain-promoted azide-alkyne cycloaddition (SPAAC) reactions to create complex molecular architectures.
• Prodrug Synthesis: Facilitates the design of targeted prodrugs by linking therapeutic agents to targeting moieties through cleavable or stable PEG-based linkers.
• Material Science: Incorporates functional groups into polymers and coatings to tailor surface properties and introduce specific chemical reactivity.

Basic Information

Product Name	n-(Acid-Peg3)-n-Bis(Peg3-Azide)
CAS No.	2182602-17-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-Azido-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatetracontan-48-oic acid; 17-Azido-3,6,9,12-tetraoxa-16-azaheptadecanoic acid, 16-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl deriv.; Carboxy-PEG3-triazole-PEG3-azide; Acid-PEG3-N-bis(PEG3-azide); Heterobifunctional PEG crosslinker, Acid/Azide; Azido-PEG3-carboxylic acid derivative; PEG-based heterofunctional linker
EINECS	Contact for details

Quality Control

Our n-(Acid-Peg3)-n-Bis(Peg3-Azide) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for research and bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional group integrity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. Allow the product to equilibrate to room temperature in a dry environment before opening to prevent moisture condensation. Store away from strong acids, bases, and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Functional Group Assay (Acid)	≥ 90%
Functional Group Assay (Azide)	≥ 90%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.