Description

(Trans)-tert-Butyl 4-Oxohexahydro-2H-Pyrano[3,2-C]Pyridine-6(7H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex fused bicyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new drugs, where consistent quality and reliable supply are critical for project timelines and regulatory success.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting the central nervous system (CNS) or infectious diseases.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.
• Academic Research: Utilized in university and institutional labs for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	(Trans)-tert-Butyl 4-Oxohexahydro-2H-Pyrano[3,2-C]Pyridine-6(7H)-Carboxylate
CAS No.	2177266-88-3
Molecular Formula	C14H23NO4
Molecular Weight	269.34 g/mol
Synonyms	tert-Butyl (3aR,7aS)-4-oxohexahydro-2H-pyrano[3,2-c]pyridine-6(7H)-carboxylate; (3aR,7aS)-tert-Butyl 4-oxohexahydro-2H-pyrano[3,2-c]pyridine-6(7H)-carboxylate; (trans)-6-(tert-Butoxycarbonyl)-4-oxohexahydro-2H-pyrano[3,2-c]pyridine; 4-Oxohexahydro-2H-pyrano[3,2-c]pyridine-6(7H)-carboxylic acid, 1,1-dimethylethyl ester, (3aR,7aS)-; BOC-protected 4-oxohexahydro-2H-pyrano[3,2-c]pyridine
EINECS	Contact for details

Quality Control

Every batch of (Trans)-tert-Butyl 4-Oxohexahydro-2H-Pyrano[3,2-C]Pyridine-6(7H)-Carboxylate is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure compliance with stringent purity specifications suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.