Description

3,3-Difluoro-1-Oxa-8-Aza-Spiro[4.5]Decane Hcl is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs). It is primarily sought by R&D teams and process chemists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures. Its specific structural motifs make it a key building block for targeting challenging biological pathways.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and improve drug-like properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing linkers or warheads in targeted protein degradation platforms.
• Agrochemical Synthesis: Employed in the research and development of new generation herbicides and fungicides with novel modes of action.
• Chemical Biology Probes: Utilized to create tool compounds for investigating enzyme function and biological pathways in academic and industrial research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke molecules for client-specific preclinical and clinical programs.

Basic Information

Product Name	3,3-Difluoro-1-Oxa-8-Aza-Spiro[4.5]Decane Hcl
CAS No.	2177266-22-5
Molecular Formula	C8H14ClF2NO
Molecular Weight	209.65 g/mol
Synonyms	3,3-Difluoro-1-oxa-8-azaspiro[4.5]decane hydrochloride; 8-Azaspiro[4.5]decane, 3,3-difluoro-1-oxa-, hydrochloride; 3,3-Difluoro-1-oxa-8-azaspiro[4.5]decane HCl; 1-Oxa-8-azaspiro[4.5]decane, 3,3-difluoro-, hydrochloride; 2177266-22-5; 3,3-Difluoro-1-oxa-8-aza-spiro[4.5]decane hydrochloride salt
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-1-Oxa-8-Aza-Spiro[4.5]Decane Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. Comprehensive Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.