Description

S-Acetyl-Peg3-Phosphonic Acid Ethyl Ester is a high-purity, functionalized PEG-phosphonate building block designed for advanced chemical synthesis. This compound is critical for researchers and manufacturers requiring precise molecular modification and linker chemistry. It is primarily utilized in the development of PROTACs, bioconjugates, and other sophisticated pharmaceutical intermediates where controlled functionalization is paramount.

Application

• PROTAC (Proteolysis Targeting Chimera) Linker Synthesis: Serves as a key component for constructing the linker region, connecting the warhead to the E3 ligase ligand.
• Bioconjugation and ADC (Antibody-Drug Conjugate) Development: Acts as a versatile spacer and functional handle for attaching payloads to antibodies, proteins, or other biomolecules.
• Pharmaceutical Intermediate: Used in the synthesis of novel drug candidates requiring PEGylated phosphonate moieties for improved solubility or targeting.
• Chemical Biology Probes: Employed to create tools for studying enzyme function, protein-protein interactions, and cellular pathways.
• Material Science and Surface Modification: Facilitates the functionalization of surfaces, nanoparticles, or polymers with specific chemical groups.
• Crosslinking Agent: Utilized in the preparation of hydrogels, polymer networks, and other crosslinked materials.

Basic Information

Product Name	S-Acetyl-Peg3-Phosphonic Acid Ethyl Ester
CAS No.	2173125-29-4
Molecular Formula	C13H27O8P
Molecular Weight	342.33 g/mol
Synonyms	2-[2-[2-(2-Acetoxyethoxy)ethoxy]ethoxy]ethyl diethyl phosphonate; Acetyl-PEG3-phosphonic acid ethyl ester; Diethyl (8-acetoxy-3,6-dioxaoctyl)phosphonate; (8-Acetoxy-3,6-dioxaoctyl)phosphonic acid diethyl ester; S-Ac-PEG3-phosphonate; Ac-PEG3-P(O)(OEt)2; PROTAC Linker 2; PEG3 Phosphonate Ester Acetate
EINECS	Contact for details

Quality Control

Our S-Acetyl-Peg3-Phosphonic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label/Certificate of Analysis. The product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere when appropriate to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
NMR Analysis	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.