Description

Azido-Peg2-Amine.Tos-Oh is a bifunctional polyethylene glycol (PEG) linker featuring an azide group and a primary amine protected as a tosylate salt. This compound is a critical reagent in bioconjugation and click chemistry, enabling the precise, high-yield coupling of biomolecules, polymers, and surfaces under mild, aqueous conditions. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science who require reliable, high-purity linkers for constructing complex molecular architectures like antibody-drug conjugates (ADCs) and hydrogels.

Application

• Bioconjugation and ADC (Antibody-Drug Conjugate) Development: Serves as a heterobifunctional crosslinker to connect targeting antibodies with cytotoxic payloads via strain-promoted azide-alkyne cycloaddition (SPAAC) or copper-catalyzed click chemistry.
• PEGylation and Polymer Modification: Used to introduce amine-reactive sites or azide handles onto peptides, proteins, and polymer backbones to improve solubility, stability, and pharmacokinetic properties.
• Surface Functionalization and Material Science: Enables the modification of nanoparticles, biosensors, and diagnostic arrays with amine or azide groups for subsequent biomolecule attachment.
• Solid-Phase Peptide Synthesis (SPPS): Acts as a versatile building block for introducing PEG spacers and functional handles during the synthesis of complex peptides and peptidomimetics.
• Chemical Biology and Probe Synthesis: Facilitates the creation of activity-based probes and fluorescent tags for studying biological processes and protein interactions.
• Hydrogel and Biomaterial Fabrication: A key component in forming crosslinked networks for tissue engineering scaffolds and controlled drug delivery systems.

Basic Information

Product Name	Azido-Peg2-Amine.Tos-Oh
CAS No.	2173092-98-1
Molecular Formula	C15H24N4O6S
Molecular Weight	388.44 g/mol
Synonyms	2-[2-(2-Azidoethoxy)ethoxy]ethanaminium 4-methylbenzenesulfonate; 11-Azido-3,6,9-trioxaundecan-1-aminium Tosylate; Amine-PEG2-Azide Tosylate Salt; N-(2-(2-(2-Azidoethoxy)ethoxy)ethyl)ammonium p-toluenesulfonate; Azido-PEG2-Amine p-Toluenesulfonate; Azido-PEG2-NH2.TosOH; 1-Amino-11-azido-3,6,9-trioxaundecane Tosylate; Azido-PEG2-Amine Tosic Acid Salt
EINECS	Contact for details

Quality Control

Our Azido-Peg2-Amine.Tos-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment supports applications in GMP-grade pharmaceutical research and other critical fields.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.