Description

2,6-Diazaspiro[3.4]Octane-2-Carboxylic Acid, 5-Methyl-, 1,1-Dimethylethyl Ester is a high-value, spirocyclic building block of significant interest in modern pharmaceutical research and development. This compound serves as a critical intermediate for constructing complex molecular architectures, enabling the discovery of novel therapeutic agents. It is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for applications in drug discovery programs.

Application

This advanced chemical intermediate is designed for sophisticated synthetic applications, particularly in the development of new active pharmaceutical ingredients (APIs).

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates targeting a range of therapeutic areas.
• Medicinal Chemistry: Used in lead optimization and structure-activity relationship (SAR) studies to improve drug-like properties.
• Proteolysis Targeting Chimera (PROTAC) Development: The spirocyclic and diaza motifs make it a valuable component for constructing linkers and warheads in bifunctional degrader molecules.
• Peptidomimetic Research: Employed to create constrained, non-peptide scaffolds that mimic peptide structures with enhanced metabolic stability.
• Chemical Biology Probes: Utilized in the synthesis of tool compounds for investigating biological pathways and target validation.
• Process Chemistry: Serves as a starting material or intermediate in the development of scalable, commercial synthetic routes for APIs.

Basic Information

Product Name	2,6-Diazaspiro[3.4]Octane-2-Carboxylic Acid, 5-Methyl-, 1,1-Dimethylethyl Ester
CAS No.	2172213-54-4
Molecular Formula	C12H22N2O2
Molecular Weight	226.32 g/mol
Synonyms	tert-Butyl 5-methyl-2,6-diazaspiro[3.4]octane-2-carboxylate; 2,6-Diazaspiro[3.4]octane-2-carboxylic acid, 5-methyl-, 1,1-dimethylethyl ester; 5-Methyl-2,6-diazaspiro[3.4]octane-2-carboxylic acid tert-butyl ester; 2-(tert-Butoxycarbonyl)-5-methyl-2,6-diazaspiro[3.4]octane; Boc-5-methyl-2,6-diazaspiro[3.4]octane
EINECS	Contact for details

Quality Control

Our production of 2,6-Diazaspiro[3.4]Octane-2-Carboxylic Acid, 5-Methyl-, 1,1-Dimethylethyl Ester adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. All materials are fully characterized using advanced analytical techniques including NMR, HPLC, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.