Description

6-Iodo-5-Methyl-[1,2,4]Triazolo[1,5-A]Pyridine is a high-purity, heterocyclic organic compound featuring a fused triazolopyridine core with iodine and methyl substituents, serving as a critical synthetic intermediate. Its value lies in providing a versatile halogenated scaffold for constructing complex molecules via cross-coupling and functional group transformations. This advanced building block is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors and other biologically active heterocycles.
• Agrochemical Research: Used in the development of new pesticides and herbicides, where the iodinated triazolopyridine structure can be leveraged for its bioactivity and as a site for further derivatization.
• Material Science Precursor: Serves as a specialized monomer or ligand precursor in the creation of advanced organic electronic materials or metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings to form carbon-carbon and carbon-heteroatom bonds.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and target engagement.
• Fine Chemical Synthesis: Employed in custom and contract synthesis for producing high-value, complex organic molecules for various industrial applications.

Basic Information

Product Name	6-Iodo-5-Methyl-[1,2,4]Triazolo[1,5-A]Pyridine
CAS No.	2172074-80-3
Molecular Formula	C7H5IN4
Molecular Weight	272.04 g/mol
Synonyms	5-Methyl-6-iodo-[1,2,4]triazolo[1,5-a]pyridine; 6-Iodo-5-methyl-1,2,4-triazolo[1,5-a]pyridine; 6-Iodo-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine (common misnomer); 2172074-80-3; Iodomethyltriazolopyridine; 5-Methyl-6-iodo-1,2,4-triazolo[1,5-a]pyridine
EINECS	Contact for details

Quality Control

Our 6-Iodo-5-Methyl-[1,2,4]Triazolo[1,5-A]Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.