Description

Azido-PEG3-Aminoacetic Acid-NHS Ester is a heterobifunctional crosslinker featuring an amine-reactive N-hydroxysuccinimide (NHS) ester and a click chemistry-ready azide group, connected by a triethylene glycol spacer. This compound is essential for creating stable, site-specific bioconjugates, enabling the controlled attachment of biomolecules, polymers, or surfaces under mild, aqueous conditions. It is a critical reagent for researchers and manufacturers in bioconjugation, proteomics, drug discovery, and advanced materials science, where precise and efficient coupling is paramount.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Site-specific labeling of antibodies, proteins, and peptides for therapeutic and diagnostic applications.
• Click Chemistry Linker: Acts as a versatile linker for copper-catalyzed azide-alkyne cycloaddition (CuAAC) to attach various probes, drugs, or polymers.
• Surface Functionalization: Modification of nanoparticles, biosensors, and microarray surfaces with bioactive molecules.
• Polymer Chemistry: Synthesis of functionalized PEG derivatives and block copolymers for drug delivery systems.
• Proteomics Research: Crosslinking agent for studying protein-protein interactions and structural analysis.
• Diagnostic Reagent Synthesis: Production of labeled antigens, antibodies, and other reagents for immunoassays.

Basic Information

Product Name	Azido-PEG3-Aminoacetic Acid-NHS Ester
CAS No.	2170240-91-0
Molecular Formula	C₁₇H₂₇N₅O₈
Molecular Weight	429.43 g/mol
Synonyms	Azido-PEG3-CH2CO2-NHS ester; 2,5-Dioxopyrrolidin-1-yl 2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)acetate; NHS-PEG3-Azide; N-(Azido-PEG3)-NHS ester; Azido-triethyleneglycol-NHS ester; Azido-PEG3-acetic acid NHS ester; 3-Azidopropyl-PEG3-NHS ester; Azido-PEG3-C2-acid NHS ester
EINECS	Contact for details

Quality Control

Our Azido-PEG3-Aminoacetic Acid-NHS Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability, consistency, and compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.