Description

Mpeg12-N3 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a methoxy group at one terminus and an azide group at the other. This compound is a critical building block in bioconjugation and click chemistry, enabling the precise, high-yield linkage of biomolecules, polymers, and surfaces. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require reliable, high-purity linkers for drug delivery systems, diagnostic assays, and hydrogel fabrication.

Application

• Bioconjugation and Linker Chemistry: Used as a spacer or linker to attach drugs, peptides, or fluorescent dyes to antibodies, proteins, or nanoparticles via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (CuAAC/SPAAC).
• PEGylation Reagent: Serves as a functional PEGylation agent to modify therapeutic proteins and peptides, improving their solubility, stability, and circulation half-life.
• Surface Functionalization: Employed to introduce azide groups onto material surfaces (e.g., gold, silica, polymers) for subsequent bio-immobilization or creating non-fouling coatings.
• Polymer and Hydrogel Synthesis: Acts as a crosslinker or monomer in the synthesis of functionalized polymers and biocompatible hydrogels for tissue engineering and controlled release applications.
• Diagnostic Probe Development: Utilized in the construction of diagnostic probes and biosensors where specific, covalent attachment of a detection moiety is required.
• ADC (Antibody-Drug Conjugate) Payload Attachment: Facilitates the site-specific conjugation of cytotoxic payloads to antibodies in ADC development pipelines.

Basic Information

Product Name	Mpeg12-N3
CAS No.	2170098-29-8
Molecular Formula	C27H55N3O13
Molecular Weight	~629.7 g/mol
Synonyms	mPEG12-Azide; Methoxy-PEG12-Azide; Azido-PEG12-OMe; α-Methoxy-ω-azido-dodecaethylene glycol; 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-Methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl azide; O-(2-Azidoethyl)-O'-methylundecaethylene glycol; mPEG12-N3; PEG-12 methyl ether azide
EINECS	Contact for details

Quality Control

Our Mpeg12-N3 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and assay, NMR for structural confirmation, and mass spectrometry for molecular weight verification. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing specifications for identity, purity, and functional group content to ensure consistency and reliability for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Under these conditions, the product is stable for at least 24 months from the date of receipt. For long-term storage, consider storing under an inert atmosphere to prevent moisture uptake and oxidation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by functional group analysis)
Water Content (KF)	≤ 1.0%
Molecular Weight (MS)	600 - 660 g/mol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.