Description

tert-Butyl 3-(Hydroxymethyl)Cyclobutane-1-Carboxylate is a high-value, multifunctional building block in advanced organic synthesis. Its structure, featuring a cyclobutane ring with both a protected carboxylic acid and a hydroxymethyl group, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and crop protection science.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in programs targeting cyclobutane-based scaffolds for improved metabolic stability and potency.
• Agrochemical Synthesis: Serves as a precursor in the design and synthesis of new-generation herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Ligand and Catalyst Development: Used to construct chiral ligands and organocatalysts, leveraging the stereochemistry of the cyclobutane ring for asymmetric synthesis.
• Material Science Monomer: Potential monomer for the synthesis of specialized polymers with unique thermal and mechanical properties derived from the strained cyclobutane structure.
• Chemical Biology Probe: Employed in the synthesis of molecular probes and tags for studying biological systems and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	tert-Butyl 3-(Hydroxymethyl)Cyclobutane-1-Carboxylate
CAS No.	2169505-33-1
Molecular Formula	C10H18O3
Molecular Weight	186.25 g/mol
Synonyms	3-(Hydroxymethyl)cyclobutane-1-carboxylic acid tert-butyl ester; 1-Cyclobutanecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester; tert-Butyl 3-(hydroxymethyl)cyclobutanecarboxylate; 3-Hydroxymethyl-cyclobutanecarboxylic acid tert-butyl ester; TBHCCB
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl 3-(Hydroxymethyl)Cyclobutane-1-Carboxylate is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.