Description

6-Azaspiro[3.4]Octane-6,7-Dicarboxylic Acid, 6-(1,1-Dimethylethyl) Ester CAS NO 2168160-42-5 is a high-value, protected spirocyclic amino acid derivative that serves as a critical building block in advanced organic synthesis. Its unique rigid, three-dimensional structure is essential for constructing complex molecular architectures with precise stereochemistry and enhanced biological activity. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, including the development of novel therapeutics and bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly in protease inhibitor and central nervous system (CNS) active molecule research.
• Medicinal Chemistry Scaffold: Used to introduce conformational constraint into peptide mimetics and small molecules, improving target binding affinity and metabolic stability.
• Agrochemical Research: Employed in the development of novel, high-performance active ingredients with specific modes of action.
• Chemical Biology Probe Synthesis: Utilized to create tool compounds for studying enzyme function and biological pathways.
• Peptidomimetic Development: The spirocyclic core mimics turn structures in peptides, facilitating the creation of more drug-like molecules.
• Asymmetric Synthesis: Serves as a starting material or chiral auxiliary in catalytic asymmetric reactions to generate enantiomerically pure products.

Basic Information

Product Name	6-Azaspiro[3.4]Octane-6,7-Dicarboxylic Acid, 6-(1,1-Dimethylethyl) Ester
CAS No.	2168160-42-5
Molecular Formula	C14H23NO4
Molecular Weight	269.34 g/mol
Synonyms	6-tert-Butyl 6,7-dihydro-1H,3H,5H-spiro[imidazo[1,5-a]pyridine-6,1'-cyclopropane]-6,7-dicarboxylate; 6-(tert-Butyl) 6-azaspiro[3.4]octane-6,7-dicarboxylate; tert-Butyl 6-azaspiro[3.4]octane-6,7-dicarboxylate; 6-Azaspiro[3.4]octane-6,7-dicarboxylic acid, 6-(1,1-dimethylethyl) ester; Spirocyclic amino acid tert-butyl ester; Protected azaspirooctane dicarboxylate
EINECS	Contact for details

Quality Control

Our 6-Azaspiro[3.4]Octane-6,7-Dicarboxylic Acid, 6-(1,1-Dimethylethyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and chiral purity analysis to ensure it meets the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.