Description

{3-Methoxybicyclo[1.1.1]pentan-1-yl}methanol is a high-value, synthetically versatile bicyclic building block. This compound is significant for its unique, highly strained [1.1.1]propellane-derived structure, which is prized in medicinal chemistry for creating novel three-dimensional molecular architectures. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for applications in drug discovery, lead optimization, and the synthesis of bioisosteres.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fragment-based drug discovery.
• Bioisostere Development: Used to replace linear or planar aromatic rings (e.g., phenyl, para-substituted phenyl) with three-dimensional, sp3-rich bicyclic structures to improve physicochemical properties of drug candidates.
• Agrochemical Synthesis: Serves as a building block for creating new pesticides and herbicides with potentially enhanced activity and environmental profiles.
• Material Science Research: Investigated as a monomer or cross-linking agent for creating polymers with unique mechanical properties due to its strained cage structure.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and protein-ligand interactions.
• Ligand and Catalyst Development: Acts as a precursor for chiral ligands or as a scaffold for organocatalysts in asymmetric synthesis.

Basic Information

Product Name	{3-Methoxybicyclo[1.1.1]pentan-1-yl}methanol
CAS No.	2167103-46-8
Molecular Formula	C8H14O2
Molecular Weight	142.20 g/mol
Synonyms	(3-Methoxybicyclo[1.1.1]pentan-1-yl)methanol; 1-(Hydroxymethyl)-3-methoxybicyclo[1.1.1]pentane; [1.1.1]Propellane, 3-methoxy-1-(hydroxymethyl)-; Bicyclo[1.1.1]pentane-1-methanol, 3-methoxy-; 3-Methoxy-[1.1.1]propellan-1-ylmethanol
EINECS	Contact for details

Quality Control

Our {3-Methoxybicyclo[1.1.1]pentan-1-yl}methanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee batch-to-batch consistency and traceability for your research and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥95% (Typical 97-99%)
Water Content (KF)	≤0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.