Description

(6R)-4-Oxo-5-Azaspiro[2.4]Heptane-6-Carboxylic Acid is a high-purity, chiral spirocyclic building block of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting complex disease pathways. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, especially for central nervous system (CNS) and metabolic disorder targets.
• Protease Inhibitor Development: Used in research for constructing spirocyclic scaffolds that mimic transition states in enzyme inhibition.
• Peptidomimetics: Serves as a constrained, non-proteinogenic amino acid analog for designing stable peptide-like molecules with enhanced bioavailability.
• Chemical Biology Probes: Employed in the creation of specialized molecular tools for studying enzyme function and cellular pathways.
• Asymmetric Synthesis: Utilized as a chiral template or auxiliary in stereoselective chemical reactions to induce desired optical activity.
• Medicinal Chemistry Optimization: Incorporated into lead compounds to improve pharmacokinetic properties such as metabolic stability and receptor selectivity.

Basic Information

Product Name	(6R)-4-Oxo-5-Azaspiro[2.4]Heptane-6-Carboxylic Acid
CAS No.	2166118-43-8
Molecular Formula	C7H9NO3
Molecular Weight	155.15 g/mol
Synonyms	(6R)-4-Oxo-5-azaspiro[2.4]heptane-6-carboxylic acid; 5-Azaspiro[2.4]heptane-6-carboxylic acid, 4-oxo-, (6R)-; (6R)-4-Oxo-5-azaspiro[2.4]heptane-6-carboxylic acid CAS 2166118-43-8; (R)-4-Oxo-5-azaspiro[2.4]heptane-6-carboxylic acid; Spirocyclic Proline Derivative; Chiral Azaspiro[2.4]heptane Acid
EINECS	Contact for details

Quality Control

Our (6R)-4-Oxo-5-Azaspiro[2.4]Heptane-6-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.