Description

tert-Butyl (S)-7-Hydroxy-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate is a high-value, chiral spirocyclic building block of significant interest in advanced organic synthesis. This compound matters because it provides a rigid, three-dimensional scaffold with multiple functional handles, enabling the construction of complex molecular architectures with precise stereocontrol. Pharmaceutical and agrochemical R&D teams need it for developing novel active ingredients, particularly as a key intermediate in the synthesis of protease inhibitors and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the research and development of new drug candidates, especially for targeting enzymes and receptors.
• Protease Inhibitor Synthesis: Serves as a core structural element in the preparation of potential inhibitors for various proteases.
• Agrochemical Active Ingredient Development: Used in creating novel, stereochemically defined pesticides and herbicides with improved efficacy.
• Asymmetric Synthesis: Employed as a building block to introduce chirality and complexity in target molecules through advanced synthetic methodologies.
• Medicinal Chemistry & SAR Studies: Utilized for structure-activity relationship (SAR) exploration to optimize the potency and selectivity of lead compounds.
• Chemical Biology Probes: Acts as a component in designing molecular probes to study biological pathways and mechanisms.

Basic Information

Product Name	tert-Butyl (S)-7-Hydroxy-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate
CAS No.	2165563-31-3
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	(S)-tert-Butyl 7-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate; (S)-2-(tert-Butoxycarbonyl)-7-hydroxy-5-oxa-2-azaspiro[3.4]octane; tert-Butyl (7S)-7-hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylate; (S)-7-Hydroxy-5-oxa-2-azaspiro[3.4]octane-2-carboxylic acid tert-butyl ester; BOC-Protected Spirocyclic Amino Alcohol; Chiral Spirocyclic BOC-Amino Ester; CAS 2165563-31-3
EINECS	Contact for details

Quality Control

Our tert-Butyl (S)-7-Hydroxy-5-Oxa-2-Azaspiro[3.4]Octane-2-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications for identity, purity (typically ≥97% by HPLC), chiral purity (≥99% ee), and impurity profiles. We adhere to cGMP principles where applicable, and our quality protocols are designed to meet the stringent requirements of pharmaceutical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.