Description

4-[(4-Aminobutyl)Amino]-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione Hcl is a high-purity, chemically defined small molecule with significant research and development potential. This compound matters as a key intermediate or active pharmaceutical ingredient (API) in the synthesis of novel therapeutic agents, particularly in oncology and immunology. Pharmaceutical R&D laboratories, biotechnology companies, and advanced chemical synthesis facilities need this material for drug discovery, process development, and analytical reference standard applications.

Application

• Pharmaceutical Intermediate: Critical building block in the synthesis of targeted protein degraders, such as Proteolysis-Targeting Chimeras (PROTACs).
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural component for novel investigational drugs.
• Biochemical Research: Used in in vitro and in vivo studies to investigate mechanisms of action related to ubiquitin-proteasome pathways.
• Reference Standard: High-purity grade is essential for analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Preclinical Studies: Supports pharmacokinetic, pharmacodynamic, and toxicology assessments in drug candidate screening.
• Chemical Biology Probe: Utilized to study specific protein interactions and cellular degradation processes.

Basic Information

Product Name	4-[(4-Aminobutyl)Amino]-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione Hcl
CAS No.	2162120-73-0
Molecular Formula	C17H22ClN5O4
Molecular Weight	395.84 g/mol
Synonyms	4-[(4-Aminobutyl)amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione hydrochloride; 4-((4-Aminobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl; 2-(2,6-Dioxopiperidin-3-yl)-4-[(4-aminobutyl)amino]isoindoline-1,3-dione hydrochloride; PROTAC-related intermediate; Cereblon ligand derivative; Thalidomide analog derivative; IMiD-based linker compound.
EINECS	Contact for details

Quality Control

Our 4-[(4-Aminobutyl)Amino]-2-(2,6-Dioxopiperidin-3-Yl)Isoindoline-1,3-Dione Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities to meet the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided and can be tailored to support regulatory filings (e.g., FDA DMF, CMC sections).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm
Assay (Titration)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.