Description

Azido-Peg5-Ch2Co2-Pfp is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring an azide group and a pentafluorophenyl (PFP) ester. This compound is specifically engineered for efficient, chemoselective bioconjugation, enabling the stable linkage of biomolecules under mild conditions. It is an essential reagent for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science, where precise and reliable conjugation chemistry is paramount.

Application

• Bioconjugation and ADC Development: Used for site-specific conjugation of antibodies, proteins, or peptides with cytotoxic drugs, fluorophores, or other payloads via click chemistry and amine coupling.
• PEGylation Reagent: Acts as a functionalized PEG spacer to modify therapeutic proteins, peptides, or nanoparticles, improving solubility, stability, and pharmacokinetics.
• Surface Functionalization: Employed to introduce azide or reactive ester groups onto material surfaces (e.g., chips, beads, nanoparticles) for subsequent immobilization of biomolecules.
• Polymer Chemistry: Serves as a building block or crosslinker in the synthesis of functionalized hydrogels, smart polymers, and drug delivery systems.
• Chemical Biology Probes: Facilitates the creation of activity-based probes or affinity tags for studying protein function and interactions in complex biological systems.
• Diagnostic Reagent Synthesis: Used in the development of diagnostic assays and imaging agents by conjugating targeting ligands with signal-generating molecules.

Basic Information

Product Name	Azido-Peg5-Ch2Co2-Pfp
CAS No.	2144777-92-2
Molecular Formula	C24H32F5N3O9
Molecular Weight	625.53 g/mol
Synonyms	Azido-PEG5-PFP ester; 2,3,5,6-Tetrafluoro-4-pentafluorophenyl 3-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoate; 5-Azido-3,6,9,12,15-pentaoxa-2-azaheptadecan-17-oic acid 2,3,5,6-tetrafluoro-4-(pentafluorophenyl) ester; N3-PEG5-PFP; Azido-PEG5-CH2CO2-Pfp; Azido-PEG5-C2-acid PFP ester; Azido-PEG5-propionic acid-PFP ester
EINECS	Contact for details

Quality Control

Our Azido-Peg5-Ch2Co2-Pfp is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent moisture absorption and oxidation. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Functional Group Assay (Azide)	≥ 90%
Functional Group Assay (PFP Ester)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.