Description

Azidoethyl-Peg2-T-Butyl Ester is a specialized bifunctional PEG linker featuring an azide group and a protected carboxylic acid. This compound is essential for facilitating click chemistry reactions, particularly copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling the precise conjugation of biomolecules and polymers. It is a critical reagent for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced materials science, where controlled, site-specific coupling is required.

Application

• Bioconjugation and ADC Development: Used as a linker to attach cytotoxic drugs, fluorescent dyes, or other payloads to antibodies, proteins, or peptides for targeted therapies and diagnostics.
• Polymer and Materials Functionalization: Enables the introduction of azide handles onto polymer backbones or material surfaces for subsequent click chemistry modifications.
• Proteomics and Chemical Biology: Serves as a tool for labeling and cross-linking biomolecules in activity-based protein profiling and other research applications.
• Peptide Synthesis: Acts as a building block for introducing PEG spacers and reactive azide groups into synthetic peptide sequences.
• Nanoparticle and Liposome Modification: Facilitates the surface engineering of nanoparticles and liposomes for drug delivery and targeting.
• Hydrogel Formation: Used as a cross-linking agent in the creation of biocompatible hydrogels for tissue engineering and controlled release systems.

Basic Information

Product Name	Azidoethyl-Peg2-T-Butyl Ester
CAS No.	2144777-83-1
Molecular Formula	C15H29N3O5
Molecular Weight	331.41 g/mol
Synonyms	2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl 2,2-dimethylpropanoate; 2,2-Dimethylpropanoic Acid 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl Ester; Azido-PEG2-t-butyl ester; t-Butyl-PEG2-azide; 11-Azido-3,6,9-trioxaundecan-1-yl pivalate; Azidoethyl-PEG2-Pivalate Ester; N3-PEG2-t-butyl ester; PEG2 Azide t-Butyl Ester
EINECS	Contact for details

Quality Control

Every batch of Azidoethyl-Peg2-T-Butyl Ester is produced and analyzed under strict quality management protocols. We employ advanced analytical techniques including NMR, HPLC, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your research and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label/Certificate of Analysis. For long-term storage under inert atmosphere, consider storing under argon or nitrogen. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 90% (by NMR)
Water Content	≤ 0.5% (KF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.