Description

Azido-Ss-Peg2-Acid is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group and a carboxylic acid, separated by a disulfide bond. This compound is engineered to enable controlled bioconjugation and release strategies, making it a critical reagent in advanced drug delivery and bioconjugation research. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing antibody-drug conjugates (ADCs), targeted therapeutics, and stimuli-responsive biomaterials.

Application

• Controlled bioconjugation for the development of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Fabrication of stimuli-responsive drug delivery systems that release payloads in reducing environments (e.g., intracellular glutathione).
• Surface functionalization of nanoparticles and biomaterials for targeted imaging and therapy.
• As a key intermediate in the synthesis of PEGylated prodrugs with cleavable linkers.
• Crosslinking agent for creating redox-sensitive hydrogels and biomaterial scaffolds.
• Tool compound in chemical biology for studying disulfide bond dynamics and protein interactions.

Basic Information

Product Name	Azido-Ss-Peg2-Acid
CAS No.	2144777-72-8
Molecular Formula	C11H19N3O6S2
Molecular Weight	353.41 g/mol
Synonyms	2-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl disulfanyl]acetic acid; Azido-PEG2-SS-acid; N3-PEG2-SS-COOH; 3,6,9-Trioxa-12-azatetradecane-1,14-dioic acid, 13-azido-5,8-dithia-; Azido-PEG2-disulfide-acid; Heterobifunctional PEG linker, Azide-SS-Acid; Azido-PEG2-SS-CH2COOH
EINECS	Contact for details

Quality Control

Our Azido-Ss-Peg2-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store the product at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.