Description

1H-Isoindole-1,3(2H)-Dione, 2-(2,6-Dioxo-3-Piperidinyl)-4-[[2-(2-Hydroxyethoxy)Ethyl]Amino]- is a high-purity, functionalized isoindole-1,3-dione derivative designed for advanced pharmaceutical research and development. This compound is a key synthetic intermediate, offering a versatile scaffold for constructing novel drug candidates, particularly in targeted protein degradation and oncology applications. It is essential for medicinal chemists and R&D teams in pharmaceutical and biotechnology companies focused on developing next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, especially for targeted protein degraders (PROTACs).
• Oncology Research: Used in the development of small-molecule inhibitors and degraders targeting specific proteins involved in cancer pathways.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Bioconjugation: The functional groups enable conjugation to linkers, antibodies, or other biomolecules for creating targeted therapies.
• Chemical Biology Probes: Utilized in the design of molecular probes to study protein function and cellular mechanisms.
• Process Development: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under GMP conditions.

Basic Information

Item	Details
Product Name	1H-Isoindole-1,3(2H)-Dione, 2-(2,6-Dioxo-3-Piperidinyl)-4-[[2-(2-Hydroxyethoxy)Ethyl]Amino]-
CAS No.	2143097-10-1
Molecular Formula	C17H21N3O6
Molecular Weight	363.37 g/mol
Synonyms	4-[[2-(2-Hydroxyethoxy)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione; 2-(2,6-Dioxo-3-piperidinyl)-4-[[2-(2-hydroxyethoxy)ethyl]amino]-1H-isoindole-1,3(2H)-dione; PROTAC Linker derivative; Thalidomide derivative with hydroxyethoxyethylamino substituent; Amino-PEG2-C2-NH-C2-OH-Phthalimide conjugate; E3 ligase ligand intermediate; Cereblon ligand analog.
EINECS	Contact for details

Quality Control

Our 1H-Isoindole-1,3(2H)-Dione derivative is manufactured under strict quality systems suitable for pharmaceutical R&D. Each batch is subjected to rigorous analytical testing including HPLC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with every shipment, detailing comprehensive specifications. We adhere to industry best practices and can support development towards cGMP standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.