Description

tert-Butyl 4,4-Difluoro-1-Oxa-6-Azaspiro[2.5]Octane-6-Carboxylate is a high-value, multifunctional spirocyclic building block designed for advanced synthetic chemistry. Its unique structure, featuring a difluorinated oxazaspiro[2.5]octane core, is engineered to introduce conformational rigidity and modulate physicochemical properties in target molecules. This compound is essential for medicinal chemists and R&D scientists in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with improved metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex heterocycles in drug discovery programs, particularly for central nervous system (CNS) and antiviral targets.
• Medicinal Chemistry Scaffold: Used to incorporate the privileged spirocyclic and fluorine motifs into candidate molecules to enhance potency, selectivity, and ADMET profiles.
• Agrochemical Research: Serves as a building block for developing new generation herbicides, fungicides, and insecticides with novel modes of action.
• Chemical Biology Probe Synthesis: Utilized in the synthesis of labeled compounds or molecular probes for studying biological pathways and target engagement.
• Material Science Precursor: Potential intermediate for creating specialty polymers or functional materials with specific fluorinated characteristics.

Basic Information

Product Name	tert-Butyl 4,4-Difluoro-1-Oxa-6-Azaspiro[2.5]Octane-6-Carboxylate
CAS No.	2137836-39-4
Molecular Formula	C11H17F2NO3
Molecular Weight	249.26 g/mol
Synonyms	6-Boc-4,4-difluoro-1-oxa-6-azaspiro[2.5]octane; tert-Butyl 4,4-difluoro-1-oxa-6-azaspiro[2.5]octane-6-carboxylate; 4,4-Difluoro-1-oxa-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester; 1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 4,4-difluoro-, 1,1-dimethylethyl ester; Boc-4,4-difluoro-1-oxa-6-azaspiro[2.5]octane; BOC-Difluoro Oxazaspiro[2.5]octane
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 4,4-Difluoro-1-Oxa-6-Azaspiro[2.5]Octane-6-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and development. All materials undergo comprehensive analytical characterization, including HPLC, NMR, and MS. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.