Description

5-Methoxyspiro[2.3]Hexan-1-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic amine structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in innovative drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in neurological and psychiatric disorder research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained spirocyclic scaffold.
• API Development: Serves as a precursor in the development and scale-up of new active pharmaceutical ingredients.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target engagement.
• Custom Synthesis: Employed by fine chemical suppliers for bespoke synthesis projects requiring complex amine derivatives.

Basic Information

Product Name	5-Methoxyspiro[2.3]Hexan-1-Amine Hydrochloride
CAS No.	2137780-65-3
Molecular Formula	C8H16ClNO
Molecular Weight	177.67 g/mol
Synonyms	5-Methoxyspiro[2.3]hexan-1-amine hydrochloride; 1-Amino-5-methoxyspiro[2.3]hexane hydrochloride; 5-Methoxy-1-azaspiro[2.3]hexane hydrochloride; Spiro[2.3]hexan-1-amine, 5-methoxy-, hydrochloride; 2137780-65-3
EINECS	Contact for details

Quality Control

Our 5-Methoxyspiro[2.3]Hexan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.